Omaha to St Louis road trip: Drive time, distance & best stops

The best road trip stops on the Omaha to St Louis drive are St Joseph, Kansas City and Fulton MO. The distance from Omaha to St Louis by car is 432 miles, with a 6h24m driving time.

Planning an Omaha to St Louis road trip itinerary

The Omaha to St Louis drive takes you from the biggest city in Nebraska to the Mississippi River in Missouri.

Omaha is the biggest city in Nebraska, and has a handful of solid attractions rather than anything truly great.

The Durham Museum has a rather eclectic set of exhibits, but the setting is marvellous – in the art deco Union Station. On a sunny day, meanwhile, the Heartland of America Park offers great views of the Missouri River.

Top Omaha experiences include electric bike rentals, scavenger hunts and the Henly Doorly Zoo and Aquarium.

St Louis is one of America’s great crossroads cities. The major landmark is the 630ft-tall Gateway Arch, which visitors can go to the top of. Other top attractions include the Cathedral Basilica of St Louis, the Missouri Botanical Garden and Busch Stadium.

Good St Louis experiences include highlight-packed trolley tours, true crime walking tours and small group tours that include going to the top of the St Louis Arch and a Mississippi River cruise.

For St Louis accommodation with personality, try the Last Hotel or the Pennywell.

Omaha to St Louis distance and driving time

By car, the distance from Omaha to St Louis is 432 miles. That makes for a driving time of around six hours and 24 minutes. The quickest route is along the I-29 then I-70.

The best stops to add to an Omaha to St Louis road trip are St Joseph, Kansas City and Fulton MO.

Omaha to St Louis road trip stops: St Joseph

The biggest city between Omaha and Kansas City is St Joseph, Missouri. It is pleasingly dotted with riverside parks and niche museums.

The Pony Express National Museum celebrates the first fast mail service to the west coast. A relay system of horse riders connected St Joseph to Sacramento in California.

Meanwhile, the Glore Psychiatric Museum looks at St Joseph’s former lunatic asylum and the treatment of mental health through the ages. And the Walter Kronkite Memorial covers the life and work of the legendary CBS news anchor.

Best stops on the Omaha to St Louis drive: Kansas City

Technically two cities spread over two different states, Kansas City has a rich cultural heritage. The Kemper Museum of Contemporary Art, Nelson-Atkins Museum of Art and American Jazz Museum show this off. Other top attractions include the National World I Memorial and the Negro Leagues Baseball Museum

Good experiences in Kansas City include an indulgent food tour of the city’s best BBQ joints, Segway tours, the Sealife Aquarium and wine-tasting trips.

Discover more things to do on the Omaha to Kansas City drive.

Omaha to St Louis drive: America’s National Churchill Museum

On March 15, 1946, the UK’s wartime Prime Minister Winston Churchill made his famous Sinews of Peace speech. It is best known for the line: “From Stettin in the Baltic to Trieste in the Adriatic, an iron curtain has descended across the Continent.”

It may surprise many to learn that the speech was made at Westminster College in Fulton, Missouri. The campus now hosts America’s National Churchill Museum, which is a massively detailed exploration of all things Churchill. Obviously there’s a big focus on the Fulton speech, but there’s a lot to discover about a fascinating, complex character.