Detroit to St Louis drive: Distance, time & best stops
The distance from Detroit to St Louis by car is 529 miles, with an 8h driving time. The best road trip stops on the Detroit to St Louis drive are Toledo OH, Indianapolis.
Planning a Detroit to St Louis road trip itinerary
The Detroit to St Louis drive connects the biggest city in Michigan and the Gateway to the West in Missouri.
Top things to do in Detroit include the excellent architecture walking tours, the Sealife Michigan Aquarium and the Legoland Discovery Centre. The Motown Museum and Ford Piquette Avenue Plant are great, too.
The capital of Indiana marries big city energy with country charm.
Top attractions in St Louis include the St Louis Motor Speedway Museum and the Children’s Museum of St Louis.
Worthwhile St Louis experiences include a Fountain Square food tour and a walking tour around the city’s highlights.
Detroit to St Louis distance and driving time
By car, the distance from Detroit to St Louis is 529 miles. That makes for a driving time of around eight hours. The quickest route is via the I-79, US-24, I-69 and I-70.
The best stops to add to a Detroit to St Louis road trip itinerary are Toledo OH, Indianapolis and Casey IL.
For more suggestions, read the guides to the Detroit to Indianapolis drive and Indianapolis to St Louis drive.
Best stops between Detroit and St Louis: Toledo OH
The National Museum of the Great Lakes in Toledo, Ohio, really embraces the scale and scope of its subject. The aim is to show how the Great Lakes have shaped America’s cultural, economic and political history, covering everything from the Underground Railroad to Prohibition-era rum-runners.
The highlight of the visit is the Col. James M. Schoonmaker, once an iron ore freighter plying its trade on the lakes, now a museum ship.
Other Toledo experiences include Toledo Zoo.
Detroit to St Louis drive: Indianapolis
The capital of Indiana marries big city energy with country charm.
Top attractions in Indianapolis include the Indianapolis Motor Speedway Museum and the Children’s Museum of Indianapolis.
Worthwhile Indianapolis experiences include a Fountain Square food tour and a walking tour around the city’s highlights.
Indianapolis to St Louis road trip attractions: Casey, Illinois
Casey, Illinois, is possibly the silliest town in the US. It has decided that its niche is going to be making Big Things, and displaying them by the side of the road. That means you can see the World’s Largest Rocking Chair, the World’s Largest Pitchfork, the World’s Largest Golf Tee and several other record-breakers.
Not all are officially the biggest on the planet, but you can also see the Big Rocking Horse, the Big Taco and the Big Anvil.
More Detroit road trips
Detroit to Atlanta | Detroit to Baltimore | Detroit to Buffalo | Detroit to Chicago | Cincinnati to Detroit | Cleveland to Detroit | Columbus to Detroit | Dallas to Detroit | Dayton to Detroit | Fort Wayne to Detroit | Grand Rapids to Detroit | Houston to Detroit | Detroit to Indianapolis | Kalamazoo to Detroit | Detroit to Knoxville | Lansing to Detroit | Louisville to Detroit | Memphis to Detroit | Detroit to Milwaukee | Detroit to Nashville | Detroit to Niagara Falls | Philadelphia to Detroit | Pittsburgh to Detroit | Toledo to Detroit.
More St Louis road trips
St Louis to Atlanta | Boston to St Louis | St Louis to Branson MO | St Louis to Chicago | St Louis to Cleveland | St Louis to Columbus | Dallas to St Louis | Denver to St Louis | Houston to St Louis | Indianapolis to St Louis | St Louis to Joplin MO | Kansas City to St Louis | St Louis to Knoxville | St Louis to Milwaukee | Nashville to St Louis | St Louis to New York City | St Louis to Oklahoma City | Omaha to St Louis | St Louis to Philadelphia | St Louis to Pittsburgh | St Louis to Springfield MO | St Louis to Tampa | St Louis to Tulsa | St Louis to Washington DC | Wichita to St Louis.