Winston-Salem to Myrtle Beach drive: Distance, time & best stops

The distance from Winston-Salem NC to Myrtle Beach SC is 214 miles, with a 3h43m driving time. The best road trip stops on the Winston-Salem to Myrtle Beach drive are the North Carolina Zoo, Cheraw State Park and the South Carolina Tobacco Museum.

Planning a Winston-Salem NC to Myrtle Beach road trip itinerary

The Winston-Salem to Myrtle Beach drive connects one of the oldest cities in North Carolina to a popular South Carolina holiday spot.

Winston-Salem NC is the birthplace of both Camel cigarettes and Krispy Kreme. The top attraction is the Old Salem Museums and Gardens, which brings together several topics across a series of preserved buildings. Wander the site, and you’ll move from decorative arts to indigenous peoples to Moravian settlers.

Other attractions include the Reynolda Museum of American Art in a handsome mansion and Historic Bethabara Park. The latter is the site of the first Moravian settlement in North Carolina.

You can also go on a guided ghost tour.

For Winston-Salem accommodation with a bit of personality, try the Kimpton Cardinal or Historic Brookstown Inn.

Myrtle Beach is a beach resort city on the Atlantic coast of South Carolina. Good Myrtle Beach experiences include a history, movies and music trolley tour, guided kayaking adventures and Huntington Beach State Park Segway tour.

There are also several shows on offer. Try the Charles Bach Wonders show for magic, Legends in Concert for tribute acts and the Polynesian Fire Luau and Dinner Show for dancing and fire stunts.

It’s worth booking Myrtle Beach accommodation in advance. For the best deals, check here.

Winston-Salem NC to Myrtle Beach SC distance and driving time

By car, the distance from Winston-Salem NC to Myrtle Beach SC is 214 miles. You can expect a driving time of around three hours and 43 minutes.

The best road trip stops on the Winston-Salem NC to Myrtle Beach drive are the North Carolina Zoo, Cheraw State Park and the South Carolina Tobacco Museum.

Winston-Salem to Myrtle Beach drive: North Carolina Zoo

The North Carolina Zoo in Asheboro NC proudly boasts that it is the world’s largest natural habitat zoo. Recreated environments include African grasslands and North American forests. Exotic animals on show include African elephants, lions and chimpanzees, while up-close encounters are available for an extra fee.

Best stops between Winston-Salem and Myrtle Beach: Cheraw State Park

Cheraw State Park is a popular camping spot which has the added bonus of an 18 hole golf course. Otherwise, the 360-acre Lake Juniper is the highlight. Kayaking, paddle boarding, canoeing and fishing are all options here, while a boardwalk runs along the lake shore.

Winston-Salem to Myrtle Beach road trip attractions: South Carolina Tobacco Museum

The town of Mullins SC grew up around the tobacco industry. Inside the former train depot, the South Carolina Tobacco Museum looks at the various stages of the tobacco-making process and the history of the industry. It includes a blacksmith shop, farm kitchen and tobacco barn.