Nashville to Greenville SC drive: Distance, time & best stops

Planning a Nashville to Greenville SC road trip itinerary

The Nashville to Greenville drive takes you from Tennessee to South Carolina.

Nashville is renowned for its country music, but the National Museum of African American Music is also in the Tennessee capital.

The best Nashville experiences include backstage tours of the Grand Ole Opry House, helicopter flights over the city and tasting tours at the Big Machine Distillery. You can also try line dancing classes, the Country Music Hall of Fame and haunted pub crawls. Or, for lavish old homes, visit Andrew Jackson’s Hermitage, the Travellers Rest Historic House Museum and Belmont Mansion.

Excellent Nashville accommodation choices include the gloriously evocative Belle Air Mansion and Inn, plus downtown’s grand dame, the Hermitage.

You can save money in Nashville by combining a tour ticket with admission to two top attractions. These combo tickets give you a half day tour of the main sights, plus entrance to the Ryman Auditorium and Country Music Hall of Fame. Find out more here.

Greenville SC is one of the fastest-growing cities in the US. It strikes a nice balance between outdoorsiness, culture and decadence. Falls Park on the Reedy brings cascades near the city center.  The Upcountry History Museum covers regional history. And the Roper Mountain Science Center has a planetarium, dinosaur adventure trail, butterfly garden and a living history farm.

Enjoyable Greenville experiences include craft cocktail tours, Segway adventures, paranormal walking tours and dessert-themed foodie tours.

Great Greenville accommodation choices include the spacious SpringHill Suites and the charming Pettigru Place Bed and Breakfast.

Nashville to Greenville SC drive

By car, the distance from Nashville to Greenville SC is 347 miles. That makes for a driving time of around five hours and 31 minutes. The quickest route is along the I-40 and US-25.

The best stops to add to a Nashville to Greenville SC road trip itinerary are Edgar Evins State Park, Knoxville TN and Asheville NC.

Nashville to Greenville drive: Edgar Evins State Park

Edgar Evins State Park is focused around the splintered arms of Center Hill Lake. It covers 6,000 acres on the Eastern Highland Rim. The landscape is steep, hilly and forested, but there are plenty of options for camping and hiking. Or, on the lake, fishing and boating.

If just dropping by, the best place to stop is the Visitor’s Centre, which has its own observation tower. This offers great views over the lake and hillsides, and you can often spot several bird species from there.

Best stops between Nashville and Greenville SC: Knoxville TN

Highlights of Knoxville include World’s Fair Park, which hosted the 1982 World’s Fair. The often-dazzling Sunsphere is the major landmark, here. You can also visit the Women’s Basketball Hall of Fame and Knoxville Museum of Art.

Other Knoxville experiences include ghost tours and downtown walking tours that pick out local secret spots, while serving up coffee and ice cream.

Nashville to Greenville SC road trip attractions: Asheville NC

In the Blue Ridge Mountains, Asheville NC is one of the main gateways to the Blue Ridge Parkway – one of America’s best road trip routes.

But there’s more to Asheville than the mountains. It’s a buzzy city of arty shops, restaurants, breweries and live music venues. The River Arts District is particularly strong on the studios and galleries front, while the lavish Biltmore Estate is the country’s biggest privately-owned home.

Top Asheville experiences include after dark ghost walks, Blue Ridge Parkway hiking tours and Jeep adventures, plus Segway tours and scenic helicopter rides.              

You can also do guided e-bike tours either downtown or in the mountains, then take a guided visit to several craft breweries.

Greenville, South Carolina
Greenville, South Carolina. Photo by Ernest_Roy/ Pixabay.

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