Memphis to Biloxi road trip: Best stops, drive time & distance

The best road trip stops on the Memphis to Biloxi drive are Oxford MS, Jackson MS and Hattiesburg MS. The distance from Memphis to Biloxi is 372 miles, with a six hour driving time.

Planning a Memphis to Biloxi road trip itinerary

The Memphis to Biloxi drive connects the home of Elvis in Tennessee with the Mississippi coast.

Memphis, Tennessee, is a pilgrimage site for Elvis fans. The King’s Graceland mansion is one of the top tourist sites in the US. But the cultural heritage extends beyond music, as you’ll discover on an African-American history tour.

Try the Rock and Soul Museum, plus the Memphis Music Hall of Fame and the 19th century Woodruff-Fontaine House.

Ways of seeing the city include ghost walks, Downtown food tours and musical bus tours. There are also guided walks down music central, Beale Street, and city tours that take you inside the legendary Sun Studios.

Top Memphis accommodation options include the Peabody, famous for its marching ducks, and the Guesthouse at Graceland.

Biloxi on the Mississippi coast is best known as a casino destination, but there’s plenty to keep non-gamblers interested. The Biloxi Lighthouse opened in 1848, and is now open for public tours. The Maritime and Seafood Industry Museum covers the region’s history, and looks at just how big a business fishing is. You can also take a cruise on one of the schooners moored outside the museum.

Also in Biloxi is Beauvoir, the lavish home of Confederate president Jefferson Davis. The mansion is open for tours.

For Biloxi accommodation, try the Scarlet Pearl Casino Resort for entertainment and the South Beach Hotel and Suites for beachside location.

Memphis to Biloxi distance and driving time

By car, the distance from Memphis to Biloxi is 372 miles. That makes for a driving time of around six hours. The quickest route heads along the I-55, US-49 and MS-67.

The best stops to add to a Memphis to Biloxi road trip itinerary are Oxford MS, Jackson MS and Hattiesburg MS.

Memphis to Biloxi road trip attractions: Oxford MS

A short detour east of the I-55, Oxford MS has a more refined air to it than many cities in Mississippi. It is a place of book shops, galleries, theatres and – of course – Ole Miss. The University of Mississippi plays a major part in creating Oxford’s vibe.

Individual highlights of the city include Rowan Oak, home of Nobel Prize-winning author William Faulkner, and the eclectic University Museum. The exhibitions inside flit from Ancient Greek antiques to scientific instruments.

Best stops between Memphis and Biloxi: Jackson MS

The capital of Mississippi has a collection of strong museums. The Mississippi Museum of Art has a great Southern art collection. The Old Capitol Museum and Mississippi Civil Rights Museum cover politics and history.

The Mississippi Museum of Natural Science is arguably Jackson’s highlight, though. It comes with a 100,000-gallon aquarium showing off the species that live on the Gulf Coast, and is within LeFleur’s Bluff State Park. That means plenty of nature trails to enjoy when the weather’s good.

Highly-reviewed Jackson MS accommodation includes the plush Westin and the more charming Old Capitol Inn.

Memphis to Biloxi drive: Hattiesburg MS

Hattiesburg MS is the fifth largest city in Mississippi, and it has something of a craft brewing scene. Try the Colludium brewpub or the Southern Prohibition Brewing taproom if you’d like to taste a few interesting beers. Otherwise, the main attractions are Hattiesburg Zoo and the African-American Military History Museum are the top attractions.

The Biloxi Lighthouse in Biloxi, Mississippi.
The Biloxi Lighthouse in Biloxi, Mississippi. Photo by SharronP/ Pixabay.

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